{"product_id":"abcam-ab248892","title":"Abcam, ab248892, Anti-DHRS7 antibody [EPR9338(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal DHRS7 antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9338(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248892 is the carrier-free version of\u003cbr\u003e\nab140596\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDHRS7 short for dehydrogenase\/reductase 7 is an enzyme involved in oxidation-reduction reactions. This protein has a molecular mass of approximately 37 kDa. As part of the short-chain dehydrogenase\/reductase family which is notable for its role in metabolizing a wide range of substrates DHRS7 is expressed in several tissues including liver kidney and brain. It contributes to the conversion of various small molecules although the specific substrates it acts on remain less completely defined.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDHRS7 influences cellular processes by participating in steroid and retinoid metabolism. It operates as an independent enzyme rather than as part of a larger complex. Its activity affects the balance of oxidized and reduced states of substrates impacting cell signaling and homeostasis. The enzyme modifies key signaling molecules potentially influencing the receptor activities that these molecules regulate therefore playing a role in cellular responses and adaptation.\u003cbr\u003e\nPathways\u003cbr\u003e\nDHRS7 integrates into metabolic and signaling pathways through its function in oxidation-reduction reactions. It participates in the steroid metabolism pathway where it perhaps interacts with cytochrome P450 enzymes that mediate a variety of biosynthetic processes. DHRS7 may also engage in the retinoid metabolic pathway related through the mutual need for enzymes capable of handling lipid-soluble vitamins and hormones. Its interaction with other enzymes in these pathways helps maintain cellular equilibrium and contributes to broader metabolic networks.\u003cbr\u003e\nDHRS7 interactions have been linked with metabolic syndrome and liver disease. Abnormal activities of DHRS7 have been observed in conditions involving disrupted metabolic states suggesting a link to liver disease through impaired processing of substrates in the liver. The altered function of this enzyme can also affect pathways involving other proteins like cytochrome P450 leading to ripple effects in metabolic disorders such as atypical steroid processing in metabolic syndrome indicating the importance of DHRS7 in maintaining normal cellular physiology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851873538217,"sku":"ab248892","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab248892","provider":"Iright","version":"1.0","type":"link"}