{"product_id":"abcam-ab248969","title":"Abcam, ab248969, Anti-PI-9 antibody [EPR8186(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PI-9 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8186(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248969 is the carrier-free version of\u003cbr\u003e\nab150400\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe PI-9 protein also known as serpinB9 is a serine protease inhibitor with a molecular mass of approximately 42 kDa. It is expressed primarily in immune cells such as cytotoxic T lymphocytes and natural killer cells as well as in some neurons and hepatocytes. The protein inhibits proteolytic enzymes to prevent unwanted cell death mainly controlling granzyme B activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPI-9 helps regulate immune cell activity and prevent autoimmunity by inhibiting granule-mediated apoptosis. It functions as part of a complex that manages cell death pathways acting as a guardian against excessive cytotoxic actions by the immune system. Its regulatory role ensures the balance between attacking pathogens and protecting host cells from unnecessary destruction.\u003cbr\u003e\nPathways\u003cbr\u003e\nPI-9 plays an integral role in the apoptotic pathway interacting with proteins like granzyme B to protect host cells from immune-mediated killing. It is also involved in the cellular response to stress especially within the immune system's cytotoxic responses. The protein's interaction with granzyme B highlights its role in maintaining the balance between immune defense and cellular protection.\u003cbr\u003e\nPI-9 has been linked to autoimmune conditions and cancer. It helps regulate autoimmune responses by preventing excessive apoptosis which could otherwise lead to tissue damage. In cancer PI-9 overexpression is sometimes observed potentially allowing tumor cells to evade immune surveillance. The relationship between PI-9 and granzyme B is important in understanding its dual role in disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851736109225,"sku":"ab248969","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab248969","provider":"Iright","version":"1.0","type":"link"}