{"product_id":"abcam-ab249133","title":"Abcam, ab249133, Anti-Palladin antibody [EPR9460(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Palladin antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9460(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249133 is the carrier-free version of\u003cbr\u003e\nab154827\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPalladin is a cytoskeletal protein that plays an important role in maintaining cell structure and function. It is often referred to simply by its name and it has a molecular weight of approximately 90 to 140 kDa depending on its isoform. Palladin is expressed in a variety of tissues but shows a higher presence in cells such as fibroblasts smooth muscle cells and cardiac tissues. This protein interacts with numerous actin-associated proteins and contributes to the organization of the actin cytoskeleton by promoting actin polymerization.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPalladin interacts with at least four actin-binding proteins to influence cellular processes such as motility and adhesion. Palladin often forms part of larger protein complexes that regulate the cytoskeleton. Through these interactions it contributes to the maintenance of cell shape and the mechanical stability of cells. Palladin’s role extends to influencing cell signaling pathways that regulate cell movement and structural integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers connect palladin functions with cytoskeletal organization and cell signaling. It participates in pathways that involve the RhoA signaling pathway and the mechanotransduction pathway. Palladin interacts closely with proteins such as profilin and VASP synergistically influencing actin polymerization. These interactions are important for various cellular activities such as migration and morphogenesis.\u003cbr\u003e\nResearchers have found palladin to be linked with conditions such as cancer and certain fibrosis. Altered expression levels of palladin can lead to enhanced metastatic potential in cancer cells. Additionally it exhibits associations with BRCA1 in breast cancer where mutations can alter cytoskeletal dynamics thereby affecting cell proliferation and migration. Palladin's overexpression is also observed in pancreatic cancer connecting it to actin-associated proteins that influence disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851913318569,"sku":"ab249133","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab249133","provider":"Iright","version":"1.0","type":"link"}