{"product_id":"abcam-ab249167","title":"Abcam, ab249167, Anti-Kinesin Heavy Chain 2 antibody [EPR10740(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal KIF2A antibody. Carrier free. Suitable for IHC-P, ICC\/IF, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10740(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249167 is the carrier-free version of\u003cbr\u003e\nab154868\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKinesin Heavy Chain 2 also known as kinesin-2 or KIF3A is a motor protein involved in intracellular transport. It has a molecular mass of about 83 kDa. Kinesin-2 functions by moving along microtubules converting chemical energy from ATP into mechanical work to transport cellular cargo. This protein primarily operates in cellular regions with high microtubule activity such as neurons and epithelial cells. Kinesin-2 is vital for ciliary function as it transports essential components along the axoneme of motile and primary cilia.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKinesin-2 operates as part of the kinesin-2 family complex which also includes KIF3B and a kinesin-associated protein (KAP). It manages the anterograde transport of proteins and vesicles necessary for ciliary growth and function. This system is essential for maintaining cilia which play roles in cell signaling and locomotion. Without the proper action of kinesin-2 ciliary assembly and maintenance become impaired leading to compromised cell function.\u003cbr\u003e\nPathways\u003cbr\u003e\nKinesin-2 is critical in the intraflagellar transport (IFT) pathway and the Hedgehog signaling pathway. In the IFT pathway kinesin-2 works closely with the IFT proteins to shuttle cargo necessary for cilia function from the cell body to the cilia tip. In the Hedgehog pathway kinesin-2 helps transport signaling molecules to cilia which is important for pathway activation. This protein interacts with the IFT-B complex ensuring efficient signal transduction necessary for correct cellular responses.\u003cbr\u003e\nKinesin-2 malfunctions associate with ciliopathies and certain types of cancer. Defective kinesin-2 function can cause ciliopathies like Bardet-Biedl syndrome due to its role in ciliary transport. Additionally disruption of kinesin-2-related transport in Hedgehog signaling links to basal cell carcinoma where this signaling pathway often becomes aberrant. These conditions emphasize the importance of kinesin-2 in proper cellular function and its contributions to human health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855997423785,"sku":"ab249167","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab249167","provider":"Iright","version":"1.0","type":"link"}