{"product_id":"abcam-ab249227","title":"Abcam, ab249227, Anti-ARL 1 antibody [EPR10595] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ARL 1 antibody. Carrier free. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10595,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249227 is the carrier-free version of\u003cbr\u003e\nab155982\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nARL 1 also known as ADP-ribosylation factor-like protein 1 is a small GTPase of the Arf family. It has a molecular mass of about 20 kDa. This protein is ubiquitously expressed in human tissues with significant expression observed in the Golgi apparatus. ARL 1 regulates intracellular vesicular trafficking and plays a role in the structural integrity of the Golgi complex.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nARL 1 interacts with multiple effectors to perform its roles in the cell. It becomes part of a complex with Golgi-associated proteins and participates in the regulation of membrane traffic between the Golgi and endosome. This protein associates with other small GTPases to control the localization and function of Golgi resident proteins impacting processes like glycosylation and secretion.\u003cbr\u003e\nPathways\u003cbr\u003e\nARL 1 is involved in important intracellular traffic pathways such as the Golgi to plasma membrane transport. It works within a network with proteins such as ARL2 and ARF1 influencing the COPI-coated vesicle cycle. ARL 1 interacts with pathways responsible for maintaining the Golgi structure and managing the trafficking of proteins and lipids.\u003cbr\u003e\nARL 1 has connections to diseases affecting the Golgi apparatus and vesicular transport like neurodegenerative disorders and cancer. It is associated with proteins like Golgin-97 and Rab6 in these contexts. Deregulation of ARL 1 function can result in altered cellular trafficking contributing to the pathogenesis of these conditions by impacting protein and lipid mislocalization.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851755114665,"sku":"ab249227","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab249227","provider":"Iright","version":"1.0","type":"link"}