{"product_id":"abcam-ab249380","title":"Abcam, ab249380, Anti-C1D antibody [EPR11122] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal C1D antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11122,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249380 is the carrier-free version of\u003cbr\u003e\nab166897\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nC1D also known as RRP40 or NOL9 is a nuclear phosphoprotein with a molecular mass of approximately 27 kDa. It functions as a component of the exosome complex which is involved in the processing and degradation of RNA. C1D shows high expression levels in the nucleus across various cell types with especially strong presence in hematopoietic tissues. This protein plays a significant role in maintaining RNA stability by binding RNA substrates and directing them for processing or degradation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein participates in the proper functioning of several complexes such as the nuclear RNA exosome complex. The exosome complex regulates RNA turnover ensuring the quality control by removing aberrant RNA molecules. C1D is essential for RNA maturation processes particularly those required for stable ribosome production and accurate gene expression. It interacts with other proteins involved in RNA processing including various RNases to achieve precise RNA regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nC1D actively engages in RNA processing and degradation pathways. It works alongside ribonucleoproteins and RNases in the exosomal pathway to manage cellular RNA levels and maintain mRNA surveillance systems. C1D also plays a role in the non-coding RNA processing pathway by interacting with proteins such as EXOSC10 which aids in proper RNA turnover and processing supporting cellular homeostasis.\u003cbr\u003e\nC1D links to conditions like autoimmune diseases and neurodegenerative disorders. Aberrations in C1D function can contribute to autoimmune conditions due to improper RNA processing which disrupts normal cellular functions and immune responses. Moreover due to its involvement in RNA stability and processing alterations in C1D are associated with neurodegenerative diseases where its interaction with proteins like TDP-43 becomes significant further highlighting its role in maintaining neurological health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851845619881,"sku":"ab249380","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab249380","provider":"Iright","version":"1.0","type":"link"}