{"product_id":"abcam-ab249398","title":"Abcam, ab249398, Anti-gamma Adaptin antibody [EPR9875(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal gamma Adaptin antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9875(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249398 is the carrier-free version of\u003cbr\u003e\nab167153\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGamma adaptin also known as AP1G1 or AP-1 gamma subunit is a protein component of the adaptor protein complex 1 (AP-1). It has a molecular mass of approximately 91 kDa and functions in the Golgi apparatus as well as in the endosomes. This protein is important for intracellular transport mechanisms and influences the sorting and trafficking of various cargo proteins. Gamma adaptin is expressed in a range of tissues in the human body where it directs specific pathways of protein trafficking and plays a major role in maintaining cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGamma adaptin facilitates the recruitment of clathrin and other cargo proteins forming an important part of the AP-1 complex. AP-1 mediates the sorting of lysosomal enzymes and other proteins from the trans-Golgi network to endosomes and lysosomes. Through interactions with cytosolic adaptor proteins gamma adaptin contributes to vesicle formation and cargo selection. By participating in the correct shipping and transport of proteins within the cell it maintains cellular homeostasis and regulates vesicular trafficking.\u003cbr\u003e\nPathways\u003cbr\u003e\nGamma adaptin plays significant roles in both clathrin-mediated endocytosis and vesicular trafficking pathways. Within these pathways gamma adaptin interacts with proteins like clathrin and other adaptor proteins such as beta adaptin and mu adaptin. These interactions ensure the proper transport of proteins between cellular organelles. Gamma adaptin ensures precise intracellular protein distribution and impacts cellular communication processes. The interplay between gamma adaptin and other transport proteins is fundamental for maintaining efficient cellular operations.\u003cbr\u003e\nGamma adaptin has been linked to certain conditions such as atherosclerosis and neurological disorders. It interacts with proteins like Hermansky-Pudlak syndrome 1 (HPS1) which plays a role in the development of these diseases. Abnormalities in the function or expression of gamma adaptin can lead to improper protein trafficking contributing to disease progression. Understanding the relationships between gamma adaptin and these diseases offers potential insights for novel therapeutic strategies targeting the faulty shipping and transport mechanisms within the cell.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851790438569,"sku":"ab249398","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab249398","provider":"Iright","version":"1.0","type":"link"}