{"product_id":"abcam-ab249406","title":"Abcam, ab249406, Anti-RBM47 antibody [EPR9658] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal RBM47 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9658,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249406 is the carrier-free version of\u003cbr\u003e\nab167164\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRBM47 also known as RNA-binding motif protein 47 plays a role in post-transcriptional gene regulation. It is a protein that weighs approximately 72 kDa. Researchers have found RBM47 mainly in the nucleus and its expression is observed in various tissues with higher levels in liver and kidney. This protein binds to RNA sequences and influences mRNA stability and splicing impacting gene expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRBM47 contributes to RNA processing and modulation of mRNA splicing. It acts independently as well as part of larger protein complexes involved in RNA metabolism. This modulation can lead to variations in protein expression which is important for cellular differentiation and response. Studies indicate that RBM47 can interact with other RNA-binding proteins such as HuR which work together to stabilize specific mRNA transcripts.\u003cbr\u003e\nPathways\u003cbr\u003e\nStudies associate RBM47 directly with the regulation of RNA stability and processing pathways. Notably it participates in pathways influencing the epithelial-mesenchymal transition (EMT) a process significant in cancer progression and metastasis. Within these pathways RBM47 works in conjunction with other RNA-binding proteins to maintain balance in RNA turnover and protein expression.\u003cbr\u003e\nRBM47 has a connection to cancer and developmental abnormalities. Its role in modifying RNA transcripts and involvement in EMT suggest it might influence cancer cell metastasis. Decreased expression of RBM47 may relate to increased cancer aggressiveness. Additionally RBM47's interactions with proteins in the RNA stability pathway highlight its potential contribution to neural developmental disorders although the precise mechanisms require further research.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851814817961,"sku":"ab249406","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab249406","provider":"Iright","version":"1.0","type":"link"}