{"product_id":"abcam-ab249435","title":"Abcam, ab249435, Anti-PHKG2 antibody [EPR9727] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PHKG2 antibody. Carrier free. Suitable for ICC\/IF, WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9727,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249435 is the carrier-free version of\u003cbr\u003e\nab167424\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPHKG2 also known as phosphorylase kinase gamma 2 is a catalytic subunit of the phosphorylase kinase (PhK) enzyme. PHKG2 has a molecular weight of approximately 44 kDa. This enzyme is responsible for the phosphorylation of serine residues in glycogen phosphorylase which is necessary for glycogen breakdown. PHKG2 is expressed mainly in muscle and liver tissues where it plays a role in the regulation of glycogen metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPhosphorylase kinase involving PHKG2 is critical for the regulation of glycogenolysis. It forms a complex with other subunits including alpha beta and delta contributing to the full enzymatic activity of PhK. As part of this multi-subunit complex PHKG2 facilitates the conversion of glycogen to glucose-1-phosphate ensuring that energy production meets cellular demands during physical activity or fasting.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe glycogenolysis process involving PHKG2 is tightly linked with the cAMP-dependent protein kinase (PKA) signaling pathway. Phosphorylase kinase gets activated by PKA under hormonal control prompting glycogen breakdown and maintaining glucose homeostasis. Additionally PHKG2's activity is connected with the insulin signaling pathway which integrates with its function to regulate carbohydrate metabolism especially relating to its interaction with proteins such as glycogen synthase and protein phosphatase 1.\u003cbr\u003e\nMutations in PHKG2 associate with Glycogen Storage Disease Type IX (GSD IX) a disorder characterized by an inability to properly break down glycogen leading to muscle weakness and hepatomegaly. PHKG2's interaction with proteins like alpha-glucosidase also links it to conditions like Pompe disease where glycogen buildup occurs due to deficient enzyme activity. Monitoring and understanding PHKG2's role in these contexts is important for developing therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851870687401,"sku":"ab249435","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab249435","provider":"Iright","version":"1.0","type":"link"}