{"product_id":"abcam-ab249441","title":"Abcam, ab249441, Anti-DLGAP4 antibody [EPR10888] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal DLGAP4 antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10888,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249441 is the carrier-free version of\u003cbr\u003e\nab168339\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDLGAP4 also known as SAPAP4 or DAP4 plays a role as a scaffolding protein at the postsynaptic density of neurons where it interacts with other proteins to facilitate synaptic signaling. This protein has a molecular mass of approximately 107 kDa. Its expression is primarily found in the brain particularly in the cerebral cortex and the hippocampus which suggests a specific role in neuronal function and behavior regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDLGAP4 participates as part of a postsynaptic complex that includes members of the DLG (discs large) protein family. This association is important for organizing and maintaining the structure of synaptic connections. The protein contributes to regulating synapse organization and plasticity which are important for learning and memory processes. Additionally it mediates interactions between the postsynaptic density components and the actin cytoskeleton aiding in the structural stability of synapses.\u003cbr\u003e\nPathways\u003cbr\u003e\nDLGAP4 acts within the glutamatergic signaling pathway where it influences the dynamics of glutamate receptors. It associates with proteins such as PSD-95 which are integral in coupling receptors and other signaling molecules. The involvement in this pathway highlights the role of DLGAP4 in modulating excitatory synaptic transmission and synaptic plasticity which are essential for cognitive functions.\u003cbr\u003e\nDisruptions in DLGAP4 expression or function have been linked to neurological diseases like schizophrenia and autism spectrum disorder. Abnormalities in DLGAP4 may affect brain circuits responsible for these conditions. Within these contexts DLGAP4 interacts with other synaptic proteins such as SHANK3 which when mutated or dysfunctional contribute to the pathophysiology of these disorders. Understanding DLGAP4's interactions can help illuminate mechanisms underlying synaptic dysfunction in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852306043049,"sku":"ab249441","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab249441","provider":"Iright","version":"1.0","type":"link"}