{"product_id":"abcam-ab249625","title":"Abcam, ab249625, Anti-GNL2 antibody [EPR11479] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal GNL2 antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11479,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249625 is the carrier-free version of\u003cbr\u003e\nab170960\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGNL2 also known as nucleolar GTP-binding protein 2 functions mechanistically as a GTP-binding protein involved in ribosome biogenesis. With a mass of approximately 68 kDa GNL2 participates in nucleolar processes. Expression of GNL2 occurs broadly within tissues but shows notable presence in proliferative cells. It belongs to the MMR1\/HSR1 GTP-binding protein family.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGNL2 interacts as part of the nucleolar complex that contributes to ribosome assembly and maturation. It assists in the stabilization and processing of ribosomal RNA precursors aiding in the production of functional ribosomes necessary for protein synthesis. This connection highlights its role in cellular proliferation and homeostasis particularly within fast-dividing cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nGNL2 interacts with several important cellular processes beyond its primary role in ribosome biogenesis. It integrates into the cell cycle regulatory pathway influencing cell cycle progression and growth. GNL2 also shows involvement with proteins such as nucleolin and nucleophosmin partners essential for its function in ribosome maturation and the regulation of nucleolar structure.\u003cbr\u003e\nGNL2 exerts influence on conditions associated with abnormal cell proliferation. It has a connection to cancers given its role in accelerating ribosome biogenesis and supporting high proliferation rates in tumor cells. GNL2's dysregulation links it with oncogenic processes often interacting with proteins like p53 an essential regulator in cancer pathways. Additionally aberrant GNL2 expression might relate to disorders involving disrupted cell cycle control.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852505567401,"sku":"ab249625","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab249625","provider":"Iright","version":"1.0","type":"link"}