{"product_id":"abcam-ab249696","title":"Abcam, ab249696, Anti-RPL7A antibody [EPR12310] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal RPL7A antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12310,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249696 is the carrier-free version of\u003cbr\u003e\nab172478\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe RPL7A protein also known as 60S ribosomal protein L7a plays a role in the structure and function of the ribosome. It is a component of the large 60S subunit of the ribosome and has a mass of approximately 29.5 kDa. RPL7A is expressed in various tissues and is involved in protein synthesis by forming part of the ribosome machinery that translates mRNA into protein.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRPL7A is part of the ribosomal complex which is essential for the translation process in cells. This protein interacts with rRNA and other ribosomal proteins to ensure the proper assembly and function of ribosomes. Its function is necessary for maintaining the fidelity and efficiency of protein synthesis. RPL7A’s presence in the ribosome allows it to influence cellular growth and proliferation by affecting how effectively proteins are produced within the cell.\u003cbr\u003e\nPathways\u003cbr\u003e\nRPL7A plays a role in the translation pathway which is critical for protein biosynthesis. This pathway involves other proteins such as RPL5 and RPL11 which also participate in ribosomal subunit formation and function. Additionally RPL7A is part of the mTOR signaling pathway a major regulator of cellular growth in which it helps modulate ribosome biogenesis and protein synthesis in response to nutrient availability.\u003cbr\u003e\nMutations or dysregulation in RPL7A have been associated with certain cancers. For instance alterations in RPL7A expression levels can disrupt normal ribosome function contributing to the pathogenesis of leukemia. The interaction of RPL7A with proteins like p53 links it to cell cycle regulation where it can influence tumor development and progression when these interactions are impaired.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851776250025,"sku":"ab249696","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab249696","provider":"Iright","version":"1.0","type":"link"}