{"product_id":"abcam-ab249735","title":"Abcam, ab249735, Anti-FBXL19 antibody [EPR11957] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal FBXL19 antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Human, Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11957,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249735 is the carrier-free version of\u003cbr\u003e\nab172961\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFBXL19 also known as F-box and leucine-rich repeat protein 19 functions as a subunit of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. This complex plays a vital role in targeting cellular proteins for ubiquitination and proteasomal degradation. The molecular mass of FBXL19 is approximately 74 kDa. FBXL19 can be found in several tissues with notable expression in the brain and reproductive organs. It also locates within the nucleus of cells where it interacts with other components of the ubiquitination machinery.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFBXL19 influences the regulation of protein stability and turnover through its participation in the SCF complex. This complex involving SKP1 CUL1 and other F-box proteins mediates ubiquitination by recognizing specific phosphorylated substrates. FBXL19 facilitates the recognition of these substrates impacting cellular processes such as cell cycle progression signal transduction and transcription regulation. The precise action of FBXL19 within these complexes highlights its role in maintaining cellular homeostasis by ensuring timely protein degradation.\u003cbr\u003e\nPathways\u003cbr\u003e\nFBXL19 is integral to the protein degradation pathway and the regulation of the cell cycle. The protein interacts with the ubiquitin-proteasome system to modulate the levels of cell cycle regulators maintaining proper cellular division and function. FBXL19 also shows interconnection with proteins such as SKP2 in the regulatory pathway of cell cycle highlighting its involvement in pathways controlling cell proliferation and differentiation.\u003cbr\u003e\nFBXL19 has links to cancer and neurodegenerative diseases. Its role in ubiquitin-mediated proteolysis affects tumor suppressor proteins and oncogenes which can contribute to oncogenesis. Dysregulation of FBXL19 activity may also impact proteins associated with neurodegenerative disorders such as tau or amyloid precursor protein suggesting a potential involvement in pathologies like Alzheimer's disease. The connection between FBXL19 these proteins and related pathways emphasizes its importance in understanding molecular mechanisms of disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851839688873,"sku":"ab249735","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab249735","provider":"Iright","version":"1.0","type":"link"}