{"product_id":"abcam-ab249746","title":"Abcam, ab249746, Anti-CELF-6 antibody [EPR10155] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal CELF-6 antibody. Carrier free. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10155,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249746 is the carrier-free version of\u003cbr\u003e\nab173282\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCELF-6 also known as CUGBP Elav-like family member 6 is a protein with a mass of approximately 55 kDa. This protein is part of the CELF family which includes members like CELF-5. CELF-6 is mainly expressed in the brain and plays roles involving post-transcriptional regulation of gene expression. It functions through binding RNA elements specifically regulating alternative splicing mRNA editing and translation. This protein significantly impacts RNA processing events helping maintain proper cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCELF-6 participates in controlling neuronal cell differentiation and function. It acts as a dynamic RNA-binding protein that can form part of larger ribonucleoprotein complexes influencing the fate of specific mRNAs. Through regulation of mRNA splicing and stability CELF-6 ensures that neurons develop and function properly. Studies have noted its substantial role in brain development where it affects the expression of genes essential for neuronal pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nCELF-6 influences post-transcriptional gene expression in neural tissues. CELF-6 is significantly involved in the MBNL1-mediated alternative splicing pathway and is known to modulate splicing activities. Its role overlaps with proteins like CELF which also participate in splicing and RNA processing regulation. The interactions between CELF proteins within these pathways highlight complex regulatory networks essential for proper RNA metabolism and neural function.\u003cbr\u003e\nCELF-6 has been linked to neurodevelopmental disorders specifically autism spectrum disorder (ASD). Abnormal expression or function of CELF-6 can lead to disrupted neural gene expression linked to ASD. Comparisons with other CELF proteins especially CELF-1 underline their collective influence on neural health. Furthermore CELF-6 alterations have been associated with epilepsy suggesting its critical role in neural excitability and signaling. Studies continue to explore the extent to which CELF-6 and its interactions contribute to the pathophysiology of such disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851763929257,"sku":"ab249746","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab249746","provider":"Iright","version":"1.0","type":"link"}