{"product_id":"abcam-ab2501","title":"Abcam, ab2501, Anti-Heparan Sulfate Proteoglycan 2\/Perlecan antibody [A7L6]","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nAnti-Heparan Sulfate Proteoglycan 2\/Perlecan antibody [A7L6] (ab2501) is a rat monoclonal antibody detecting Heparan Sulfate Proteoglycan 2\/Perlecan in  Western Blot, IP, IHC-P, IHC-Fr . Suitable for  Cow, Fish, Human, Mouse, Pig, Rat . - Over 30 publications - Trusted since 2002\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rat,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:A7L6,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Rat, Mouse, Cow, Fish, Pig,\u003cbr\u003e\nApplications:IHC-Fr, IHC-P, WB, ICC, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Tissue preparation containing Basement membrane-specific heparan sulfate proteoglycan core protein protein. The exact immunogen used to generate this antibody is proprietary information.P98160,\u003cbr\u003e\nSpecificity:Recognizes domain IV of heparan sulphate proteoglycan 2 \/ perlecan. The reactivity is independent of the galactosaminoglycan moieties. Therefore, the epitope is not sensitive to heparitinase treatment.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Heparan Sulfate Proteoglycan 2\/Perlecan antibody [A7L6] (ab2501) is a rat monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr) in Cow, Fish, Human, Mouse, Pig, Rat samples.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-Heparan Sulfate Proteoglycan 2\/Perlecan [A7L6] (ab2501) was first used in a scientific publication in 2002 and has been cited over 30 times in peer-reviewed journals.\u003cbr\u003e\nReviewed by scientists\u003cbr\u003e\nAnti-Heparan Sulfate Proteoglycan 2\/Perlecan [A7L6] (ab2501) has over 10 independent reviews from customers.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHeparan Sulfate Proteoglycan 2 also known as Perlecan is a large multidomain proteoglycan with a mass of over 500 kDa. It contains heparan sulfate chains that contribute to its role in the extracellular matrix. Perlecan is expressed in various tissues including cartilage basement membranes and vascular tissues. It interacts with other matrix proteins providing structural integrity and influencing cell behavior.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPerlecan plays a critical role in cell adhesion proliferation and growth factor signaling. It is an important component of basement membranes and forms a structural complex with other matrix proteins. Its interaction with heparan sulfate chains enables binding with various ligands such as growth factors and cytokines optimizing their availability and functionality at the cell surface. This interaction is essential in tissue maintenance and repair processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nPerlecan participates in the regulation of the Wnt and Hedgehog signaling pathways. These pathways influence key developmental processes and dictate cellular differentiation and migration. Perlecan and its heparan sulfate chains modulate protein interactions within these pathways notably affecting proteins such as Dsh and Ctnnb1 which are essential in signal transduction.\u003cbr\u003e\nPerlecan involvement has been linked with tumorigenesis and cardiovascular diseases. Aberrations in its structure or expression can alter cellular microenvironments impacting key processes like angiogenesis and metastasis. Furthermore its interaction with growth factors can facilitate the progression of diseases like cancer highlighting its connection with proteins such as VEGF and TGF-beta which play major roles in disease modulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855750910121,"sku":"ab2501","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab2501","provider":"Iright","version":"1.0","type":"link"}