{"product_id":"abcam-ab250147","title":"Abcam, ab250147, Anti-Bif-1 antibody [EPR11857] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Bif-1 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11857,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The immunogen used for this product shares 81% homology with Endophilin-B2. Cross-reactivity with this protein has not been confirmed experimentally.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250147 is the carrier-free version of\u003cbr\u003e\nab180135\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBif-1 also known as BAX-interacting factor-1 is a protein involved in the regulation of apoptosis and autophagy. It has an approximate mass of 23 kDa and is expressed in various tissues including the brain and immune cells. The protein is an important player in mitochondrial dynamics participating in membrane curvature required for mitochondrial fission.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein participates in mitochondrial fragmentation and membrane remodeling. Bif-1 is a component of the endophilin B1 complex which is involved in the regulation of apoptosis. It interacts directly with BAX a pro-apoptotic protein and enhances BAX translocation to mitochondria thereby facilitating the release of cytochrome c and subsequent cell death processes. It also influences autophagic processes by binding to Beclin1.\u003cbr\u003e\nPathways\u003cbr\u003e\nBif-1 functions as an important link between the apoptosis and autophagy pathways. It facilitates the intrinsic apoptotic signaling pathway where BAX and Beclin1 play significant roles. In these pathways the protein controls cellular homeostasis and stress responses linking to other key regulators such as Bak and p53 which are involved in tumor suppression and DNA damage responses.\u003cbr\u003e\nBif-1 has connections to neurodegenerative diseases and cancer. Its dysregulation is associated with impaired autophagy and apoptosis contributing to the pathogenesis of Alzheimer's disease. In cancers altered expression of Bif-1 affects tumor growth and resistance to cell death interacting with proteins such as p53 and BAX which are pivotal in controlling cellular proliferation and survival.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848547913897,"sku":"ab250147","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250147","provider":"Iright","version":"1.0","type":"link"}