{"product_id":"abcam-ab250245","title":"Abcam, ab250245, Anti-BTN1A1 antibody [EPR14173] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal BTN1A1 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14173,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250245 is the carrier-free version of\u003cbr\u003e\nab180605\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBTN1A1 also known as Butyrophilin Subfamily 1 Member A1 is a type I transmembrane protein with a molecular mass of approximately 57 kDa. It is a member of the immunoglobulin superfamily and expressed in various tissues with notably high expression in the mammary gland during lactation. BTN1A1 plays a significant role in milk fat globule secretion by forming complexes on the apical surface of mammary epithelial cells. The protein consists of an extracellular region a transmembrane domain and a cytoplasmic tail.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAs a component of the milk fat globule membrane BTN1A1 participates in lipids metabolic processes and immunological interactions. It does not function as part of a large protein complex yet its interactions on the cell surface are essential for the stability and transport of fat globules. The presence of BTN1A1 impacts immune cell regulation due to its predicted involvement with T cells an important component of the adaptive immune system.\u003cbr\u003e\nPathways\u003cbr\u003e\nBTN1A1 contributes to both lactation and immune regulation processes. It is particularly involved in the fatty acid metabolism pathway impacting lipid biosynthesis and transport. Within immune regulation pathways BTN1A1 might interact with related proteins such as BTN2A1 also in the butyrophilin family which modulates T cell activity. These pathway involvements reflect BTN1A1's dual role in lipid homeostasis and immune surveillance.\u003cbr\u003e\nBTN1A1 has a potential link to breast cancer and certain autoimmune diseases. Given its expression in the mammary gland altered levels of BTN1A1 might associate with breast tumor development. Additionally its role in immune regulation suggests a connection to autoimmune disorders where improperly modulated T cell responses occur. Further research is necessary to completely understand the protein's involvement in these diseases and any interaction with proteins like BTN2A1 in pathological contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851939893417,"sku":"ab250245","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250245","provider":"Iright","version":"1.0","type":"link"}