{"product_id":"abcam-ab250315","title":"Abcam, ab250315, Anti-MRPL20 antibody [EPR12592] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal MRPL20 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12592,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250315 is the carrier-free version of\u003cbr\u003e\nab181058\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMRPL20 or mitochondrial ribosomal protein L20 is a component of the mitochondrial ribosome involved in protein synthesis within the mitochondria. MRPL20 weighs around 27 kDa and is key in the formation and function of the mitochondrial large ribosomal subunit. It is expressed ubiquitously with high levels in tissues that demand significant energy such as the brain heart and skeletal muscle.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMRPL20 plays a role in protein assembly within mitochondria forming part of the 39S ribosomal subunit. It interacts with RNA and other ribosomal proteins to ensure proper mitochondrial protein translation. MRPL20 works in close relationship with other mitochondrial ribosomal proteins such as MRPL3 and MRPL15 facilitating efficient mitochondrial biogenesis and energy production.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe MRPL20 protein is significant in the mitochondrial translation pathway which is important for respiratory chain complex assembly. It aids in encoding proteins necessary for oxidative phosphorylation. MRPL20 associates with proteins like MRPS12 and MRPS18A which participate in mitochondrial protein synthesis integrating into the broader mitochondrial function and energy production network.\u003cbr\u003e\nMRPL20 is linked to mitochondrial dysfunction and related diseases such as mitochondrial encephalomyopathy and cardiomyopathy. These conditions can result from mutations affecting MRPL20 disrupting mitochondrial protein synthesis and impairing energy production. MRPL20 interacts with proteins like MFN2 which are also involved in mitochondrial maintenance and have roles in disorders related to energy deficits in the human body.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852506386601,"sku":"ab250315","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250315","provider":"Iright","version":"1.0","type":"link"}