{"product_id":"abcam-ab250382","title":"Abcam, ab250382, Anti-Cytochrome b-c1 complex subunit 9\/UQCR10 antibody [EPR8178] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Cytochrome b-c1 complex subunit 9\/UQCR10 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8178,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250382 is the carrier-free version of\u003cbr\u003e\nab181154\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCytochrome b-c1 complex subunit 9 also known as UQCR10 is a small protein with a mass of approximately 7.6 kDa. It functions as a component of the cytochrome b-c1 complex which is an essential part of the mitochondrial electron transport chain. One can find UQCR10 expressed primarily in the inner mitochondrial membrane critical for cellular respiration and energy production. The role of UQCR10 within the complex is to stabilize the interaction between other subunits therefore maintaining the integrity of the cytochrome b-c1 complex.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUQCR10 participates in facilitating electron transfer within the cytochrome b-c1 complex also known as Complex III of the mitochondrial respiratory chain. This complex comprises multiple protein subunits including cytochrome b cytochrome c1 and others. UQCR10 aids in the translocation of protons across the mitochondrial membrane contributing to the proton gradient necessary for ATP synthesis. This electron transfer process is vital for the production of cellular energy.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of UQCR10 is integral to the oxidative phosphorylation pathway. This pathway involves several key processes within mitochondria that result in the synthesis of ATP. UQCR10 alongside cytochrome c1 and other subunits assists in the electron transfer from ubiquinol to cytochrome c. By facilitating these electron transfer reactions UQCR10 plays an important role in aerobic respiration and cellular energy metabolism.\u003cbr\u003e\nUQCR10 has connections to mitochondrial disorders and neurodegenerative diseases. Mutations affecting the cytochrome b-c1 complex can lead to mitochondrial dysfunction impacting energy production and leading to conditions such as Leigh syndrome and other mitochondrial myopathies. The role of UQCR10 in stabilizing the cytochrome complex makes it relevant in understanding disease mechanisms alongside related proteins like cytochrome c1 that can influence disease outcomes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851946184873,"sku":"ab250382","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250382","provider":"Iright","version":"1.0","type":"link"}