{"product_id":"abcam-ab250404","title":"Abcam, ab250404, Anti-Calpain 9 antibody [EPR13422] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Calpain 9 antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13422,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250404 is the carrier-free version of\u003cbr\u003e\nab181178\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCalpain 9 also known as CAPN9 is a calcium-dependent cysteine protease enzyme that plays a role in proteolytic processes. It has a molecular mass of approximately 114 kDa. Capable of autolytic activation Calpain 9 becomes functional in the presence of calcium ions. Expression of Calpain 9 occurs mainly in the gastrointestinal tract particularly in the stomach and small intestine. This enzyme has distinct activities compared to other calpains partially due to its unique conserved domains affecting substrate specificity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme assists in maintaining cellular homeostasis through its proteolytic functions. Calpain 9 does not usually exist as part of large protein complexes but it interacts dynamically with substrates and other cellular components. It participates in various cellular processes such as cell cycling differentiation and apoptosis. Essentially Calpain 9 regulates specific protein modifications and degradations which affect cellular structural integrity and signal transduction mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nCalpain 9 influences intracellular signaling and remodeling being particularly linked to the non-canonical Wnt signaling pathway and calcium signaling pathways. Within these pathways Calpain 9 works alongside other related proteins such as GSK-3β in the Wnt pathway and calmodulin in calcium signaling. These pathways are important for the modulation of cellular responses to stimuli and contribute to the fine-tuning of cellular activities impacting tissue development and repair processes.\u003cbr\u003e\nThe dysregulation of Calpain 9 takes part in gastric cancer progression and susceptibility to inflammatory bowel disease (IBD). It contributes to tumorigenesis when proteolytic balance within cellular environments shifts unfavorably. Furthermore alterations in Calpain 9 expression or activity influence interactions with proteins like E-cadherin within cancer progression. Understanding these relationships may provide insights into novel therapeutic targets or diagnostic markers for specific diseases involving impaired protease regulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851851288745,"sku":"ab250404","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250404","provider":"Iright","version":"1.0","type":"link"}