{"product_id":"abcam-ab250417","title":"Abcam, ab250417, Anti-TTC4 antibody [EPR13381] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TTC4 antibody. Carrier free. Suitable for ICC\/IF, IP, WB, IHC-P and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13381,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250417 is the carrier-free version of\u003cbr\u003e\nab181194\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTTC4 also known as Tetratricopeptide Repeat Protein 4 has a molecular mass of approximately 44 kDa. It functions as a molecular chaperone assisting in the folding and stability of other proteins. TTC4 contains tetratricopeptide repeat (TPR) motifs which play a role in protein-protein interactions. These motifs enable TTC4 to interact with various cellular proteins. It is expressed widely in human tissues with higher levels observed in the heart brain and testis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe tetratricopeptide repeats in TTC4 facilitate its role as a part of multiprotein complexes. This protein takes part in regulating important cellular processes like cell cycle control and stress response. TTC4 assists in stabilizing proteins during cellular stress ensuring proper cellular function under adverse conditions. It may also interact with heat shock proteins (HSPs) contributing to protein homeostasis in cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis protein is involved in important cellular processes including the signal transduction pathways and protein quality control pathways. TTC4 is notably involved in the chaperone-mediated autophagy pathway where it regulates the turnover and recycling of damaged proteins. It relates to proteins such as Hsp70 which are central to cellular stress response mechanisms. This relationship plays an important role in maintaining protein stability and cellular function.\u003cbr\u003e\nTTC4's role in maintaining cellular protein stability links it to conditions caused by protein misfolding. Misregulation in its function may contribute to neurodegenerative diseases such as Alzheimer's disease where excessive protein aggregation occurs. Additionally TTC4 interacts with proteins like Tau which are important in the pathogenesis of Alzheimer's. Aberrations in TTC4 might also influence cancer progression due to its involvement in cell cycle regulation linking it to proteins such as p53 known for its tumor suppressor role.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860416614569,"sku":"ab250417","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250417","provider":"Iright","version":"1.0","type":"link"}