{"product_id":"abcam-ab250433","title":"Abcam, ab250433, Anti-PRMT7 antibody [EPR13495] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PRMT7 antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13495,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250433 is the carrier-free version of\u003cbr\u003e\nab181214\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPRMT7 short for Protein Arginine Methyltransferase 7 plays an important role in the methylation of arginine residues on target proteins. It acts as a type of enzyme known for catalyzing the transfer of methyl groups. PRMT7 appears in several tissues although its expression is noted in higher amounts in brain and testis tissues. This protein weighs approximately 78 kDa and undergoes different modifications influencing its activity and localization. Researchers sometimes refer to PRMT7 simply as PRMT-7.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe activity of this protein regulates gene expression by modifying histones and non-histone proteins affecting chromatin structure. It does not typically act as part of a large complex but can associate with other proteins to achieve specific functions. PRMT7 influences processes like protein signaling RNA processing and cell cycle control illustrating its diverse roles in cellular biology.\u003cbr\u003e\nPathways\u003cbr\u003e\nPRMT7 participates intricately in pathways involving transcriptional regulation. It regulates pathways such as the arginine methylation pathway and is connected to transcription factor binding pathways. Its action intertwines with other methyltransferases and specific epigenetic regulators such as PRMT5 highlighting the crosstalk between different protein modification pathways within cells.\u003cbr\u003e\nPRMT7 has a connection to cancer and neurodevelopmental disorders. Altered expression or activity of PRMT7 associates with oncogenesis making it a potential target in cancer research with some studies pointing out possible links to breast cancer. In neurodevelopmental disorders the protein's role in gene expression regulation suggests its involvement. In such conditions interactions with proteins such as FMR1 linked to Fragile X syndrome highlight the importance of understanding PRMT7's function to unravel its therapeutic implications.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851857088681,"sku":"ab250433","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250433","provider":"Iright","version":"1.0","type":"link"}