{"product_id":"abcam-ab250559","title":"Abcam, ab250559, Anti-TSP50 antibody [EPR8675(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TSP50 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8675(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250559 is the carrier-free version of\u003cbr\u003e\nab181993\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTSP50 also known as testis-specific protease 50 is a serine protease with a molecular mass of approximately 53 kDa. This protein is expressed mainly in human testes and has also been observed in certain cancerous tissues. TSP50 shows protease activity which may contribute to its role in cellular processes. While the precise mechanical functions remain not entirely understood TSP50 is involved in the degradation of substrates within cells suggesting a part in protein turnover or processing.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe action of TSP50 is significant in the regulation of cell growth and differentiation. While not part of a well-defined complex its activity affects cellular homeostasis. The expression pattern of TSP50 mainly restricted to reproductive tissues and some cancer cell types highlights its role in reproductive functions and links to oncogenesis. Its regulation impacts cellular environments possibly promoting proliferation and invasive behavior of cancer cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nTSP50 engages in signaling processes tied to cell cycle regulation and apoptosis. The protein plays a part in pathways related to ubiquitin-dependent proteolysis and might interact with proteins such as p53 a major regulatory protein of the cell cycle and apoptosis. By modulating protein degradation TSP50 can influence cell fate decisions potentially tipping the balance toward growth or death depending on the cellular context.\u003cbr\u003e\nIncreased TSP50 expression associates with certain cancers including breast and prostate cancer. Its expression correlates with malignant progression tumor growth and metastasis. TSP50's interaction with proteins like BRCA1 a known factor in breast cancer risk emphasizes its role in tumor biology. These connections suggest that TSP50 could serve as a potential biomarker for cancer diagnosis or a target for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851909583017,"sku":"ab250559","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250559","provider":"Iright","version":"1.0","type":"link"}