{"product_id":"abcam-ab250626","title":"Abcam, ab250626, Anti-CRABP1 antibody [EPR7905] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal CRABP1 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7905,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250626 is the carrier-free version of\u003cbr\u003e\nab182573\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCRABP1 also known as Cellular Retinoic Acid Binding Protein 1 is a small protein with a molecular mass of around 15 kDa. It mainly binds and transports retinoic acid a metabolite of vitamin A that is important for cell growth and differentiation. CRABP1 is typically expressed in various tissues including the skin eyes and central nervous system. It provides cells with a way to regulate retinoic acid levels acting as a buffer and maintaining proper cellular functioning.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCRABP1 plays a significant role in modulating the access of retinoic acid to nuclear receptors by controlling its availability in the cell. It is not part of a large protein complex but instead often acts independently to manage intracellular retinoic acid. The protein ensures normal development and maintenance of tissues by influencing gene transcription related to cell differentiation and proliferation. This regulation is important in processes like embryogenesis and skin regeneration.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral intricate signaling cascades involve CRABP1 such as the retinoic acid signaling pathway and the retinoid metabolic pathway. In these pathways CRABP1 directly interacts with proteins like Retinoic Acid Receptors (RARs) to modulate their activity. By regulating retinoic acid levels CRABP1 influences cellular response outcomes which is important for processes like morphogenesis and homeostasis.\u003cbr\u003e\nCRABP1 has been linked to specific conditions like skin disorders and certain types of cancer. Altered levels of CRABP1 can impact the normal regulation of retinoic acid leading to dysfunctional cell proliferation and differentiation. The protein's interaction with RAR-related proteins plays a role in these diseases where disrupted signaling can result in anomalous cellular behavior contributing to pathological development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851945562281,"sku":"ab250626","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250626","provider":"Iright","version":"1.0","type":"link"}