{"product_id":"abcam-ab250754","title":"Abcam, ab250754, Anti-PPIC antibody [EPR15355] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PPIC antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15355,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250754 is the carrier-free version of\u003cbr\u003e\nab184552\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein PPIC also known as Peptidylprolyl Isomerase C functions as a molecular chaperone by catalyzing the cis-trans isomerization of proline residues in peptide chains. This activity accelerates protein folding. PPIC has a molecular mass of approximately 18 kDa. You can find PPIC expression in many tissues with significant levels in the heart and skeletal muscle. It belongs to the cyclophilin family known for its role in facilitating protein folding due to its peptidyl-prolyl cis-trans isomerase activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPPIC's role extends beyond simple protein folding as it forms part of a larger complex that assists in protein trafficking and assembly. It interacts with other proteins to ensure the proper folding and structural integrity of nascent peptides influencing their stability and function. The capacity to influence protein dynamics positions PPIC as an integral component of cellular homeostasis and protein quality control mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nPPIC assumes important roles in cellular signaling and protein trafficking pathways. Notably it participates in pathways related to immunomodulation and stress response assisting in protein folding under stress conditions. Its interaction with calcineurin a protein phosphatase indicates its involvement in the immune response and other signaling pathways mediated by calcium ions where it can impact the function of other cyclophilin family proteins.\u003cbr\u003e\nPPIC associates with conditions like cardiac hypertrophy and ischemic diseases. Its involvement in these conditions likely connects to its role in maintaining protein homeostasis and response to cellular stress. Moreover PPIC's interaction with the calcineurin\/NFAT pathway implicates it in cardiovascular diseases as this pathway participates in heart disease pathology linking to proteins such as NFAT and calmodulin. Understanding PPIC's specific contributions to these diseases could provide insights into therapeutic targets for treating related disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851796435113,"sku":"ab250754","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250754","provider":"Iright","version":"1.0","type":"link"}