{"product_id":"abcam-ab250897","title":"Abcam, ab250897, Anti-Claudin 17 antibody [EPR15483] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Claudin 17 antibody. Carrier free. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15483,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250897 is the carrier-free version of\u003cbr\u003e\nab186744\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nClaudin 17 also known as CLDN17 is a member of the claudin family of proteins essential for the formation of tight junctions in epithelial cells. Weighing approximately 24 kDa Claudin 17 plays a mechanical role in regulating paracellular transport which means it controls the flow of molecules between cells. Expression of this protein occurs mainly in the kidney and liver epithelia where it contributes to the barrier function of these tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nClaudin 17 functions to maintain the selective permeability of epithelial barriers. It is part of the tight junction complex a group of proteins that includes other claudins occludin and junctional adhesion molecules. This complex ensures that tissues maintain homeostasis by controlling the diffusion of solutes and ions across epithelial layers. Claudin 17 also contributes to the polarity and differentiation of epithelial cells impacting how these cells interact with their environment.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers have identified Claudin 17 as an important player in the regulation of the paracellular transport pathway and its involvement in maintaining the epithelial barrier function. It participates in pathways that involve sodium and chloride ion transport closely interacting with proteins like Claudin 8 and Claudin 1. Such interactions balance ion transport and cellular permeability important for proper epithelial function.\u003cbr\u003e\nResearchers have explored Claudin 17's involvement in conditions such as electrolyte imbalance and kidney dysfunction. Its altered expression has been connected to Claudin 3 in renal disorders impacting tight junction integrity. Misregulation could lead to disruptions in ion balance contributing to disease progression. Understanding how Claudin 17 relates to these conditions can drive advancements in therapeutic strategies against epithelial barrier-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851732504745,"sku":"ab250897","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250897","provider":"Iright","version":"1.0","type":"link"}