{"product_id":"abcam-ab250940","title":"Abcam, ab250940, Anti-WISP3 antibody [EPR14769] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal WISP3 antibody. Carrier free. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14769,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250940 is the carrier-free version of\u003cbr\u003e\nab187666\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nWISP3 also known as CCN6 is a protein with a mass of approximately 39 kDa. It belongs to the CCN family of proteins which are involved in diverse cellular processes. WISP3 is primarily expressed in cartilage and connective tissues such as bone and skin. This protein interacts with growth factors and other signaling molecules influencing cellular growth and maintenance. WISP3's mechanical role involves binding to extracellular matrix components which affects cell adhesion and communication.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nWISP3 functions as an important modulator of cartilage homeostasis and matrix production. It takes part in processes that regulate cartilage integrity and interacts with other extracellular proteins to maintain the physical properties of connective tissues. One of its roles includes modulating interactions with the insulin-like growth factor (IGF) binding proteins. These interactions support tissue structural integrity and cellular communication essential for development and repair mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nWISP3 participates in the regulation of the Wnt signaling pathway. This pathway plays an important role in chondrogenesis and osteogenesis processes vital for bone and cartilage development. WISP3 influences the activity of key proteins within this pathway such as Wnt and Frizzled to modulate gene expression. It also interacts with proteins like beta-catenin which are pivotal to these signaling cascades therefore contributing to tissue specification and differentiation processes.\u003cbr\u003e\nWISP3 mutations are associated with Progressive Pseudorheumatoid Dysplasia (PPD) and have connections to conditions affecting skeletal development. PPD is a disorder characterized by cartilage degeneration leading to joint pain and stiffness. WISP3's interaction with IGF-related proteins is critical in these conditions as dysregulation can lead to improper tissue development and homeostasis. Studies also link abnormal WISP3 activity to osteoarthritis where its altered expression might contribute to the disease pathology by affecting cartilage cell signaling and matrix production.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852502585513,"sku":"ab250940","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250940","provider":"Iright","version":"1.0","type":"link"}