{"product_id":"abcam-ab250954","title":"Abcam, ab250954, Anti-C14orf166 antibody [EPR15799] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal C14orf166 antibody. Carrier free. Suitable for ICC\/IF, IP, WB, IHC-P and reacts with Human, Rat, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15799,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250954 is the carrier-free version of\u003cbr\u003e\nab188326\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nC14orf166 also known as TIPH2 is a protein encoded by the C14orf166 gene. This protein has a molecular mass of approximately 38 kDa. It plays a role in RNA metabolism particularly in the export of messenger RNA (mRNA) from the nucleus to the cytoplasm. Expression of C14orf166 occurs in various tissues with higher levels often found in actively dividing and metabolically active cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nC14orf166 integrates into the transcriptional regulation process by forming part of a complex involved in RNA processing. It interacts with components of the transcription-export (TREX) complex which is essential for coupling mRNA processing with export. This integration allows C14orf166 to assist in maintaining efficient mRNA transport and translation important for normal cellular function and stress response.\u003cbr\u003e\nPathways\u003cbr\u003e\nC14orf166 significantly influences gene expression regulation and participates in the mRNA processing pathways. It interacts with proteins such as Aly\/REF and UAP56 within the TREX complex importantly impacting the efficiency of mRNA export. By securing efficient mRNA transport C14orf166 supports critical biological pathways like the unfolded protein response and cellular proliferation.\u003cbr\u003e\nAberrant expression or function of C14orf166 has connections to cancer particularly breast cancer. Dysregulation in its function can lead to improper mRNA export contributing to tumorigenesis. Furthermore C14orf166 shows relations to viral infections; for example it intersects with pathways involving Nucleophosmin (NPM1) which are exploited by viruses such as influenza. This makes C14orf166 a potential target for therapeutic strategies aiming to manage these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851642327209,"sku":"ab250954","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250954","provider":"Iright","version":"1.0","type":"link"}