{"product_id":"abcam-ab250962","title":"Abcam, ab250962, Anti-DMAP1 antibody [EPR18179] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal DMAP1 antibody. Carrier free. Suitable for WB, ICC\/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR18179,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250962 is the carrier-free version of\u003cbr\u003e\nab188407\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDMAP1 also known as DNA methyltransferase 1-associated protein 1 functions mechanically as a regulatory component in several cellular processes. With an approximate mass of 53 kDa this protein exhibits widespread expression in various tissues reflecting its diverse roles within the cell. The primary function of DMAP1 involves transcriptional regulation through histone modification and chromatin remodeling influencing gene expression patterns.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDMAP1 participates in gene silencing and regulation through integration into the NuRD complex a critical multi-subunit complex involved in chromatin remodeling and deacetylation of histones. By modulating chromatin structure DMAP1 influences DNA accessibility and transcriptional activation or repression. This protein provides a scaffold for the recruitment of additional factors essential for transcriptional regulatory complexes further enhancing its role in maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nDMAP1 plays a significant role in the DNA damage response and repair pathways particularly through its interactions with proteins such as DNA methyltransferase 1 (DNMT1) and components of the NuRD complex. Through these interactions DMAP1 aids in the repair of damaged DNA and maintenance of genomic stability. This involvement highlights its connection to cellular processes like cell cycle control and development linking it to broader biological networks.\u003cbr\u003e\nDMAP1 displays associations with various cancers and neurological disorders reflecting its importance in maintaining proper cellular function. Aberrations in DMAP1 activity or expression have been observed in certain cancers where its interaction with proteins like DNMT1 and components of chromatin remodeling complexes may contribute to tumorigenesis. Similarly its disruption can affect neurodevelopmental processes possibly linking it to neurodegenerative diseases. Understanding DMAP1's role in these conditions can provide insights into therapeutic targets and disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851744530601,"sku":"ab250962","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250962","provider":"Iright","version":"1.0","type":"link"}