{"product_id":"abcam-ab250994","title":"Abcam, ab250994, Anti-AFG2 antibody [EPR14038] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal AFG2 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14038,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250994 is the carrier-free version of\u003cbr\u003e\nab189519\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAFG2 also known as ATP-dependent metalloprotease FtsH2 is an essential protein involved in protein quality control within mitochondria. This protein acts mechanically as a protease enabling the degradation of misfolded or damaged proteins preventing accumulation within the mitochondrial matrix. AFG2 has a molecular mass of approximately 80 kDa. It is expressed across various tissues predominantly in those with high-energy demands such as cardiac and skeletal muscles.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFtsH2 forms part of the m-AAA protease complex. This complex consists of other subunits that work together to maintain mitochondrial function. AFG2 contributes to mitochondrial protein homeostasis by degrading unassembled or faulty proteins. It also plays a significant role in the processing of mitochondrial ribosomal proteins ensuring efficient ribosome function and mitochondrial protein synthesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nAFG2 contributes significantly to mitochondrial biogenesis and the oxidative phosphorylation system. It interacts with other proteins such as paraplegin to regulate mitochondrial function and network maintenance. AFG2 ensures proteostasis within the mitochondria directly impacting cellular energy production. Its involvement in pathways ensures the balance of mitochondrial dynamics influencing cellular metabolism and energy distribution.\u003cbr\u003e\nAlterations in AFG2 activity often associate with neurodegenerative diseases such as hereditary spastic paraplegia and spinocerebellar ataxia. Mutations or dysregulation of AFG2 can disrupt mitochondrial proteostasis and function leading to these conditions. Additionally the protein is linked to paraplegin whose mutations may result in similar mitochondrial dysfunction emphasizing the interconnectedness of mitochondrial proteases in maintaining neurological health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851916529833,"sku":"ab250994","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab250994","provider":"Iright","version":"1.0","type":"link"}