{"product_id":"abcam-ab251071","title":"Abcam, ab251071, Anti-ATP5L2 + ATP5L antibody [EPR15636] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ATP5L2 antibody. Carrier free. Suitable for ICC\/IF, IP, WB, IHC-P and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15636,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251071 is the carrier-free version of\u003cbr\u003e\nab191417\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nATP5L2 and ATP5L are subunits of the mitochondrial ATP synthase complex also known as Complex V which plays an important role in cellular energy production. ATP5L also known as OLigo1 consists of approximately 19 kDa mass. ATP5L2 has a similar role and size. Both subunits are essential parts of the F1F0 ATP synthase complex located in the inner mitochondrial membrane. These proteins are expressed in tissues with high energy demands such as cardiac and skeletal muscles liver and neuronal tissue.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese subunits contribute to ATP synthesis which is critical for providing the energy required for various cellular functions. They are integral parts of the F1F0 ATP synthase complex which couples proton transport across the inner mitochondrial membrane to ATP generation from ADP and inorganic phosphate. This process is important for maintaining cellular energy balance and disruptions can lead to impaired cellular functions or energy deficits.\u003cbr\u003e\nPathways\u003cbr\u003e\nATP5L and ATP5L2 are integral to the oxidative phosphorylation pathway part of cellular respiration. This pathway is critical for efficient ATP production and involves other complexes such as NADH dehydrogenase and cytochrome c oxidase. These subunits interact with essential proteins like ATP5B another ATP synthase subunit ensuring the ATP synthase complex properly functions within this pathway.\u003cbr\u003e\nAltered expression or mutations in ATP synthase complex components including ATP5L and ATP5L2 can link to metabolic disorders such as mitochondrial myopathy and neurodegenerative diseases like Alzheimer's. These disorders often involve other proteins such as cytochrome c and amyloid precursor protein which further disrupt mitochondrial function and cellular energy homeostasis. Understanding these connections provides insight into the potential therapeutic targets for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851740565673,"sku":"ab251071","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab251071","provider":"Iright","version":"1.0","type":"link"}