{"product_id":"abcam-ab251123","title":"Abcam, ab251123, Anti-Jarid2 antibody [EPR6357(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Jarid2 antibody. Carrier free. Suitable for ChIP, WB, ICC\/IF and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR6357(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, ChIPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251123 is the carrier-free version of\u003cbr\u003e\nab192252\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nJarid2 also known as Jumonji or Jumonji AT-rich interactive domain 2 serves important functions in chromatin dynamics. It is a protein with a mass of approximately 125 kDa and plays a role as a regulatory factor in gene expression. Jarid2 expresses across several tissues particularly in those undergoing developmental processes such as the heart and central nervous system. The protein helps to recruit other proteins to chromatin impacting the regulation of gene activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nJarid2 interacts with the polycomb repressive complex 2 (PRC2) which modulates chromatin structure to suppress gene transcription. This interaction is key for the protein's role in epigenetic regulation. As a component of PRC2 Jarid2 influences the methylation of histone H3 at lysine 27 (H3K27) a modification critical for controlling developmental genes' expression. Its function ensures proper regulation of gene programs that affect cell fate decisions during embryogenesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nJarid2 integrates into the gene silencing pathways involving PRC2 influencing pathways like the Wnt\/β-catenin signaling pathway. This influence occurs by modulating target genes that PRC2 controls such as those involved in cellular differentiation. Additionally it relates to proteins such as Ezh2 another PRC2 member. Together these components maintain repression of genes impacting cell proliferation and differentiation.\u003cbr\u003e\nJarid2 proves significant in conditions like cardiac hypertrophy and certain cancers. Its deregulation may lead to altered expression of genes necessary for cardiac muscle cell size and function contributing to hypertrophy. In cancer changes in Jarid2 expression or function can disrupt normal growth control as seen in interactions with proteins like Suz12 another PRC2 associate. Understanding these connections helps to outline potential therapeutic targets for intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860430868649,"sku":"ab251123","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab251123","provider":"Iright","version":"1.0","type":"link"}