{"product_id":"abcam-ab251132","title":"Abcam, ab251132, Anti-NDUFC2 antibody [EPR16499] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal NDUFC2 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16499,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251132 is the carrier-free version of\u003cbr\u003e\nab192265\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNDUFC2 also known as NADH:ubiquinone oxidoreductase subunit C2 is a protein component of the mitochondrial complex I. It has a molecular mass of approximately 14.4 kDa. This protein is expressed within the mitochondria of various tissues with significant expression observed in high energy-demanding tissues such as the brain heart and muscles. NDUFC2 does not have a catalytic role but contributes to the structural stability of complex I.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNDUFC2 plays a role as part of the mitochondrial respiratory chain complex I also known as NADH:ubiquinone oxidoreductase. This complex catalyzes the initial step of electron transport helping transfer electrons from NADH to ubiquinone. By contributing to this process NDUFC2 supports ATP production through oxidative phosphorylation which is essential for cellular energy metabolism. Being part of such a complex structure NDUFC2 interacts closely with other subunits of complex I.\u003cbr\u003e\nPathways\u003cbr\u003e\nNDUFC2 involves itself in the oxidative phosphorylation and the citric acid cycle. These pathways are vital for energy conversion and metabolic processes. Within oxidative phosphorylation NDUFC2 relates to proteins such as NDUFB10 and NDUFS1 which are additional components of complex I. This protein along with its complex counterparts ensures efficient electron transport and ATP synthesis.\u003cbr\u003e\nNDUFC2 associates with mitochondrial disorders that stem from complex I deficiencies. Such diseases include Leigh syndrome a severe neurological disorder and mitochondrial encephalomyopathy. Interactions with other complex I proteins like NDUFS3 and NDUFV1 highlight the role of NDUFC2 in these conditions. Mutations or deficiencies in NDUFC2 can impact cellular energy metabolism contributing to the pathophysiology of these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851822387369,"sku":"ab251132","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab251132","provider":"Iright","version":"1.0","type":"link"}