{"product_id":"abcam-ab251346","title":"Abcam, ab251346, Anti-AG-3 antibody [EPR19606] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal AG-3 antibody. Carrier free. Suitable for ICC\/IF, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR19606,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra), ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251346 is the carrier-free version of\u003cbr\u003e\nab201464\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAG-3 also known as protein AG is a protein of about 45 kDa. This target is predominantly expressed in the cytoplasm of liver cells though it can also be found in other tissues in lower amounts. AG-3 has been identified as a protein that plays an important role in various cellular processes. Its structural domains allow it to interact with a range of biomolecules which can contribute to its diverse functions in the cell.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAG-3 enables essential cellular processes such as signal transduction and metabolic regulation. As a component of a larger protein complex AG-3 helps maintain cellular homeostasis by modulating enzymatic activities. Its presence in the complex allows for precise control and fine-tuning of cellular responses to external stimuli. Moreover AG-3 facilitates the transportation of important metabolites and ions ensuring proper cellular functionality.\u003cbr\u003e\nPathways\u003cbr\u003e\nAG-3 significantly contributes to the MAPK signaling pathway and the insulin signaling pathway. Within these pathways AG-3 interacts with proteins like ERK1\/2 and IRS proteins playing a role in cellular proliferation differentiation and metabolism. The involvement of AG-3 in these pathways exemplifies its importance in controlling cellular growth and metabolic processes making it a focal point for studies related to these functions.\u003cbr\u003e\nAG-3 is linked to conditions like type 2 diabetes and liver diseases. Alterations in AG-3 expression or function can disrupt normal cellular processes leading to the development or progression of these diseases. AG-3 interacts with insulin signaling proteins such as IRS-1 and any imbalance can contribute to insulin resistance and metabolic syndrome. Similarly aberrant levels of AG-3 in liver cells are associated with liver dysfunction suggesting a critical role for AG-3 in maintaining liver health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851832152233,"sku":"ab251346","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab251346","provider":"Iright","version":"1.0","type":"link"}