{"product_id":"abcam-ab251434","title":"Abcam, ab251434, Anti-KA1 antibody [EPR18322] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal KA1 antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR18322,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251434 is the carrier-free version of\u003cbr\u003e\nab205537\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe KA1 domain also known as the Kinase Associated-1 domain is an important structural component in certain proteins. The KA1 domain exhibits a molecular mass of approximately 8-10 kDa depending on its specific protein context. It plays an important role in targeting and binding within the cell. The KA1 domain is expressed in various cell types particularly those in the brain and muscle tissue where it contributes to cellular signaling and function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe KA1 domain of proteins helps regulate several important cellular processes. It is often part of larger protein complexes where it assists in localization and anchoring to specific structures in the cell. The domain influences various cellular activities including the assembly of signaling molecules and interaction with phospholipids. By contributing to the regulation of protein kinases and phosphatases the KA1 domain maintains critical cellular functions across different cell types.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe KA1 domain integrates into the regulation of mitogen-activated protein kinase (MAPK) pathways and protein kinase A (PKA) signaling. These pathways play essential roles in cell growth apoptosis and other signaling processes. The KA1 domain often collaborates with other proteins such as PKC (Protein Kinase C) to maintain proper signaling cascade function and ensure accurate cellular responses.\u003cbr\u003e\nThe KA1 domain's function can link to neurodegenerative diseases and cancer. Alterations in proteins containing the KA1 domain have been associated with unregulated cell growth or improper signaling cascades often seen in cancerous tissues. The KA1 domain also interacts with proteins like tau in neurons potentially impacting neurodegenerative conditions by affecting cell signaling and structure. These interactions highlight the KA1 domain's importance in contributing to disease pathways and inform therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852379771049,"sku":"ab251434","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab251434","provider":"Iright","version":"1.0","type":"link"}