{"product_id":"abcam-ab251530","title":"Abcam, ab251530, Anti-2-methyladenosine (m2A) antibody [EPR -19851-59] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal 2-methyladenosine (m2A) antibody. Carrier free. Suitable for IP, ELISA and reacts with Modified Nucleic Acid samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR -19851-59,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nApplications:IP, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Has been developed to discriminate between the modified base 2-methyladenosine (m2A) and the unmodified counterpart Adenosine (A).\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251530 is the carrier-free version of\u003cbr\u003e\nab211495\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\n2-methyladenosine (m2A) is a modified nucleoside that plays a significant role in RNA structures impacting RNA stability and function. It is an adenosine derivative where a methyl group is added to the nitrogen at position 2 of the adenine ring altering its chemical properties. This modification has a relatively small molecular mass of approximately 281.3 Da. m2A is found primarily in tRNA and rRNA molecules within the cell contributing to their proper folding and stability. It is ubiquitously expressed across various tissues reflecting its broad functional significance.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe modification of RNA by 2-methyladenosine contributes significantly to RNA processing and function. It plays a role in the structural integrity and proper folding of tRNA and rRNA by maintaining the stability of the RNA molecules they modify. m2A acts within ribonucleoprotein complexes where it influences the recognition and interaction between RNA and protein components. This modification ensures the accuracy of translation by maintaining the correct conformation of the RNA molecules involved in protein synthesis.\u003cbr\u003e\nPathways\u003cbr\u003e\n2-methyladenosine engages in essential biological processes such as translation and RNA processing. It is involved in the ribosome biogenesis pathway which is important for protein synthesis in cells. Within this pathway m2A interacts with other RNA modifications and proteins like the ribosomal proteins and various RNA-binding proteins that guide RNA through the maturation process. The presence of m2A aids the efficient assembly of ribosomal units necessary for the synthesis of proteins.\u003cbr\u003e\nAltered levels of 2-methyladenosine have been implicated in disorders related to dysfunction in protein synthesis. Aberrant m2A modification has been linked to certain cancers wherein improper RNA processing might contribute to uncontrolled cellular proliferation. Additionally it relates to neurodegenerative diseases where misfolded proteins result from translation dysregulation. In this context m2A modifications can affect the function of proteins such as ribosome-associated proteins and those involved in RNA methylation influencing disease outcomes through changes in RNA stability and processing.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851928785065,"sku":"ab251530","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab251530","provider":"Iright","version":"1.0","type":"link"}