{"product_id":"abcam-ab251682","title":"Abcam, ab251682, Anti-Myt1\/MTF1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Myt1\/MTF1 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYT1 aa 300-450.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MYT1 aa 300-450. The exact immunogen used to generate this antibody is proprietary information.Q01538\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMyt1 also known as Membrane-associated tyrosine- and threonine-specific Cdc2-inhibitory kinase is a part of the Myt family of serine\/threonine protein kinases. The molecular weight of Myt1 is approximately 58 kDa. Myt1 is expressed in several tissues with higher levels observed in the central nervous system. This protein is known for regulating cell cycle progression particularly during the G2\/M transition by phosphorylating cyclin-dependent kinases.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMyt1 plays a significant role in the control of cell cycle checkpoints. It forms part of a larger regulatory complex involving other kinases such as Wee1 to ensure proper cell division by preventing premature entry into mitosis. Myt1 achieves this by inactivating CDK1 through phosphorylation which is a critical step in maintaining cell cycle integrity in response to cellular stresses and DNA damage.\u003cbr\u003e\nPathways\u003cbr\u003e\nMyt1 integrates into the cell cycle regulation pathway impacting the G2\/M checkpoint pathways. It functions alongside Wee1 and related kinases to exert fine control over mitotic entry ensuring that any damaged DNA is repaired before the cell divides. Myt1's actions are important for proper cell cycle progression and maintaining genomic stability making it an important player in the processes that govern cellular proliferation.\u003cbr\u003e\nMyt1 has associations with various cancers due to its role in controlling cell division. When Myt1 function is disrupted it can lead to unchecked cell proliferation and tumorigenesis. Studies also connect Myt1 with Neurodevelopmental Disorders as its expression patterns affect neuronal differentiation and development. In these contexts Myt1 interacts with proteins like Wee1 highlighting its involvement in pathological states where cell cycle dysregulation and improper development take place.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854232604841,"sku":"ab251682","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab251682","provider":"Iright","version":"1.0","type":"link"}