{"product_id":"abcam-ab254450","title":"Abcam, ab254450, Maraviroc, CCR5 Antagonist","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 513.7 Da, Purity \u0026gt;98%. Potent and selective CCR5 antagonist. Blocks binding of MIP-1 alpha (IC 50  = 3.3 nM), MIP-1 beta (IC 50 = 7.2 nM) and RANTES (IC 50  = 5.2 nM) to CCR5 in radioligand binding competition assays. Potent anti-HIV activity. Blocks HIV-1 gp120 binding to CCR5 (IC 50  = 6.4 nM) preventing cell-cell fusion. Induces macrophage repolarization with anti-tumor effects.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:376348-65-1,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:513.7 Da,\u003cbr\u003e\nMolecular formula:C29H41F2N5O,\u003cbr\u003e\nPubChem:3002977,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 25 mM,\u003cbr\u003e\nBiochemical name:Maraviroc,\u003cbr\u003e\nBiological description:Potent and selective CCR5 antagonist. Blocks binding of MIP-1 alpha (IC50 = 3.3 nM), MIP-1 beta (IC50= 7.2 nM) and RANTES (IC50 = 5.2 nM) to CCR5 in radioligand binding competition assays. Potent anti-HIV activity. Blocks HIV-1 gp120 binding to CCR5 (IC50 = 6.4 nM) preventing cell-cell fusion. Induces macrophage repolarization with anti-tumor effects.,\u003cbr\u003e\nCanonical smiles:CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C,\u003cbr\u003e\nIsomeric smiles:CC1=NN=C(N1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C,\u003cbr\u003e\nInChi:InChI=1S\/C29H41F2N5O\/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22\/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)\/t23-,24+,25?,26-\/m0\/s1,\u003cbr\u003e\nInChiKey:GSNHKUDZZFZSJB-HLMSNRGBSA-N,\u003cbr\u003e\nIUPAC Name:4,4-difluoro-N-[(1S)-3-[(1S,5R)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSolutions in DMSO may be stored at -20°C for up to 3 months.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847497437353,"sku":"ab254450","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab254450","provider":"Iright","version":"1.0","type":"link"}