{"product_id":"abcam-ab254451","title":"Abcam, ab254451, BI-D1870, RSK Inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 391.4 Da, Purity \u0026gt;98%. Cell-permeable, ATP-competitive p90 ribosomal S6 kinase (RSK) inhibitor (RSK1 IC 50  = 31 nM; RSK2 IC 50  = 24 nM; RSK3 IC 50  = 18 nM; RSK4 IC 50  = 15 nM). Selective (10 to 100-fold) over MST2, GSK-3 beta, MARK3, CK1 and Aurora B. Inhibits RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in cell models. May have RSK-independent effects on mTORC1-p70S6K and p21WAF1\/CIP1 pathways.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:501437-28-1,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:391.4 Da,\u003cbr\u003e\nMolecular formula:C19H23F2N5O2,\u003cbr\u003e\nPubChem:25023738,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 25 mM,\u003cbr\u003e\nBiochemical name:2-((3,5-difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one,\u003cbr\u003e\nBiological description:Cell-permeable, ATP-competitive p90 ribosomal S6 kinase (RSK) inhibitor (RSK1 IC50 = 31 nM; RSK2 IC50 = 24 nM; RSK3 IC50 = 18 nM; RSK4 IC50 = 15 nM). Selective (10 to 100-fold) over MST2, GSK-3 beta, MARK3, CK1 and Aurora B. Inhibits RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in cell models. May have RSK-independent effects on mTORC1-p70S6K and p21WAF1\/CIP1 pathways.,\u003cbr\u003e\nCanonical smiles:CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C,\u003cbr\u003e\nInChi:InChI=1S\/C19H23F2N5O2\/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12\/h7-11,27H,5-6H2,1-4H3,(H,22,23,24),\u003cbr\u003e\nInChiKey:DTEKTGDVSARYDS-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-(3,5-difluoro-4-hydroxyanilino)-5,7-dimethyl-8-(3-methylbutyl)-7H-pteridin-6-one\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSolutions in DMSO may be stored at -20°C for up to 1 month.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847502450857,"sku":"ab254451","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab254451","provider":"Iright","version":"1.0","type":"link"}