{"product_id":"abcam-ab254730","title":"Abcam, ab254730, Anti-TSPAN1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TSPAN1 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Tetraspanin-1 aa 100 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human Tetraspanin-1 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O60635\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTSPAN1 also known as Tetraspanin-1 is a protein encoded by the TSPAN1 gene. It is part of the tetraspanin family and is characterized by four transmembrane domains. This protein has a mass of approximately 25 kDa. TSPAN1 is mainly expressed in epithelial tissues including the skin lung and gastrointestinal tract. By forming complexes with other proteins TSPAN1 integrally contributes to various cellular processes like proliferation adhesion and migration through its role in organizing the cell membrane microdomains.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTSPAN1 interacts with cell surface proteins to regulate important cellular activities. A notable characteristic of TSPAN1 is its involvement in the formation of the tetraspanin-enriched microdomains (TEMs). These microdomains facilitate interactions between various cell surface receptors and signaling molecules. This formation often includes integrins which play an important role in cell adhesion and signal transduction. TSPAN1 influences processes such as cell migration invasion and proliferation typically by modulating the activity of these integrins within the TEMs.\u003cbr\u003e\nPathways\u003cbr\u003e\nTSPAN1 modulates the PI3K\/Akt signaling pathway. The protein interacts with other tetraspanins and integrins to affect this signaling cascade which is critical for cell growth and survival. Additionally TSPAN1 connects with other signaling pathways that involve proteins like E-cadherin affecting cell-to-cell junctions and impacting epithelial integrity and function. These pathways highlight the diverse roles of TSPAN1 in maintaining cellular structure and function through its interactions.\u003cbr\u003e\nTSPAN1 shows strong associations with cancer progression particularly in gastric and colorectal cancers. The protein's role in cell proliferation and migration links it to these malignancies often showing overexpression in tumor tissues. In these cancers TSPAN1 interacts with proteins like integrins and PI3K driving oncogenic processes. Alterations in TSPAN1 expression or function may relate to disease prognosis indicating its potential as a biomarker or therapeutic target in cancer-related research.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854149767337,"sku":"ab254730","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab254730","provider":"Iright","version":"1.0","type":"link"}