{"product_id":"abcam-ab254771","title":"Abcam, ab254771, Anti-BZW2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal BZW2 antibody. Suitable for IHC-P, WB and reacts with Human, Rat, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human BZW2 aa 200-350.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human BZW2 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.Q9Y6E2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBZW2 also known as Basic Leucine Zipper and W2 Domain-Containing Protein 2 is a leucine zipper protein involved in the regulation of translation. It has other names like HSPC017 and 25FL. The molecular weight of BZW2 is approximately 46 kDa. This protein is expressed in various tissues with high levels in the pancreas and placenta. Its key mechanical role involves interacting with ribosomal subunits to modulate translation initiation particularly under conditions that require altered protein synthesis rates.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSeveral critical roles situate BZW2 in cellular growth and proliferation. It acts as a translation regulator and integrates into ribosomal complexes during the protein synthesis process. BZW2 augments the synthesis of proteins by accelerating the assembly of initiation complexes. Furthermore BZW2 indirectly affects cell cycle progression by coordinating with other translational regulators. Its expression levels correlate with rapidly dividing tissues hinting at its role in growth and development.\u003cbr\u003e\nPathways\u003cbr\u003e\nBZW2 plays an integral part in the mTOR signaling pathway and the integrated stress response (ISR) pathway. In the mTOR pathway BZW2 collaborates with other initiation factors to enhance protein synthesis related to cellular growth. Within the ISR it adjusts protein translation in response to cellular stress maintaining balance in protein homeostasis. BZW2's interaction with proteins like eIF2α highlights its significance in translational control during stress conditions.\u003cbr\u003e\nAlterations in BZW2 expression relate to cancer and neurodegenerative disorders. Abnormal regulation of BZW2 can lead to increased cell proliferation linking it to cancer development particularly in aggressive tumor types. It also connects with proteins like p53 in cancer pathways affecting apoptosis. Additionally dysfunction in the ISR involving BZW2 has implications in neurodegenerative diseases potentially through its role in stress response and protein folding affecting neuronal survival.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848579010729,"sku":"ab254771","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab254771","provider":"Iright","version":"1.0","type":"link"}