{"product_id":"abcam-ab254898","title":"Abcam, ab254898, Anti-RPL18 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal RPL18 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RPL18 aa 50 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human RPL18 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q07020\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRPL18 also known as Ribosomal Protein L18 is a component of the 60S large ribosomal subunit. It possesses a molecular weight of approximately 22 kDa. RPL18 is highly expressed in various tissues including the liver brain and pancreas. The protein plays an important role in protein synthesis by aiding in the assembly and function of ribosomes essential cellular machinery for translating mRNA into polypeptides.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRPL18 functions as part of the ribosomal complex facilitating mRNA translation into proteins. This protein is integral to the structure of the ribosome which serves as the platform for accurate peptide bond formation between amino acids. RPL18 like other ribosomal proteins contributes to the stability and efficiency of the ribosome's function during the translation process. Its presence ensures the proper alignment and interaction of ribosomal RNA and other ribosomal proteins.\u003cbr\u003e\nPathways\u003cbr\u003e\nRPL18 is involved in key processes like the protein synthesis pathway and the ribosomal biogenesis pathway. In these pathways RPL18 interacts closely with other ribosomal proteins such as RPL5 and RPL11 which together form the core of the ribosomal assembly machinery. It also plays a role in the regulation of p53 through its interaction with these and other ribosomal proteins that influence cellular stress responses and cell cycle arrest.\u003cbr\u003e\nAlterations in RPL18 levels or function can be linked to cancer and Diamond-Blackfan anemia. In cancer biology changes in ribosomal proteins including RPL18 may lead to disruptions in the normal patterns of protein synthesis contributing to tumorigenesis. In Diamond-Blackfan anemia a disorder characterized by bone marrow failure mutations in ribosomal proteins like RPL18 can impair ribosome function and affect hematopoiesis. RPL18's association with these conditions often involves interactions with key proteins such as p53 highlighting its broader impact on disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854181126313,"sku":"ab254898","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab254898","provider":"Iright","version":"1.0","type":"link"}