{"product_id":"abcam-ab255336","title":"Abcam, ab255336, Anti-Orai3 antibody [EPR22575-17] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ORAI3 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Mouse, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22575-17,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab255336 is the carrier-free version of\u003cbr\u003e\nab254260\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOrai3 is a protein known as a part of the calcium release-activated calcium (CRAC) channel family. It is also referred to as Orai calendar in certain contexts. This protein serves as a critical component in the highly selective process of calcium ion entry across the plasma membrane. Orai3 has a mass of approximately 33 kDa. It is expressed predominantly in tissues like the pancreas lung and immune system which often require tight regulation of calcium homeostasis for their proper function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOrai3 plays an essential role in cellular calcium signaling important for various cell functions such as gene expression secretion and metabolism. It often combines with other subunits of the Orai family like Orai1 to form functional calcium channels. Orai3 may form different channel complexes affecting the amplitude and kinetics of calcium entry. Its presence ensures that cells can adapt to specific physiological contexts where calcium influx is required.\u003cbr\u003e\nPathways\u003cbr\u003e\nOrai3 is a significant part of the store-operated calcium entry (SOCE) pathway which activates when intracellular calcium stores get depleted. This pathway is important for maintaining cellular calcium and proteins like STIM1 work closely with Orai3 to initiate calcium influx. The interplay between STIM1 and Orai3 ensures proper signal transduction essential for processes like T-cell activation and other immune responses.\u003cbr\u003e\nOrai3 has implications in certain cancers and cardiovascular diseases. In some cancer types like breast cancer overexpression of Orai3 contributes to cell proliferation and survival which can lead to tumor progression. Similarly in cardiovascular diseases altered function or expression of Orai3 may impact calcium regulation leading to issues such as hypertension. Its association with STIM1 in these disorders highlights the cooperative role they play in maintaining cellular health emphasizing the importance of regulated calcium influx in normal and disease states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851781951657,"sku":"ab255336","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab255336","provider":"Iright","version":"1.0","type":"link"}