{"product_id":"abcam-ab25585","title":"Abcam, ab25585, PE Anti-MHC class II I E kappa antibody [14-4-4S]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal HB2J antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 5 publications. Immunogen corresponding to Tissue preparation containing MHC class II I E kappa protein.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:14-4-4S,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nConjugation:PE,\u003cbr\u003e\nExcitation\/Emission:Ex: 480;565nm, Em: 578nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody is specific to an epitope on mouse I-E kappa MHC class II alloantigen. The antibody reacts with the I-E kappa class II alloantigen on cells from mice of the H-2d, H-2p, and H-2r haplotypes. The antibody has also been reported to crossreact with the rat class II alloantigen RT1D.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.3Preservative: 0.09% Sodium azideConstituents: PBS, 16% Sucrose, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMHC class II I-E kappa also known as I-Ek is a protein involved in the immune system's antigen-presenting function. It is part of the major histocompatibility complex (MHC) class II molecules which are important for presenting exogenous antigens to CD4+ T helper cells. MHC class II molecules have a molecular mass that ranges from 50 to 70 kDa. I-Ek is usually expressed on the surface of professional antigen-presenting cells like dendritic cells macrophages and B cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nI-Ek is involved in the immune response by forming a complex with peptides derived from external sources. This complex is then presented on the cell surface to facilitate recognition by CD4+ T helper cells which play a critical role in adaptive immunity. I-Ek's interactions are essential for triggering T cell-mediated immune responses important in fighting infections and maintaining immune tolerance. Researchers widely study this protein to understand immune response modulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nMHC class II I-Ek is a component of the antigen processing and presentation pathway critical in adaptive immune responses. Within this pathway the I-Ek protein interacts with the invariant chain and memory B cells to assist in antigen presentation. It also participates in the intricate network where it communicates with CD4+ receptor-bearing T cells important for effective immune system activation.\u003cbr\u003e\nMHC class II I-Ek has significant implications in autoimmune diseases such as rheumatoid arthritis and type 1 diabetes. Aberrant expression or malfunction of I-Ek can contribute to these conditions by promoting inappropriate immune responses against self-antigens. The protein interacts with other molecules like human leukocyte antigen (HLA) linked to autoimmunity serving as potential research targets for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855413661865,"sku":"ab25585","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab25585","provider":"Iright","version":"1.0","type":"link"}