{"product_id":"abcam-ab256410","title":"Abcam, ab256410, Anti-IMPA2 antibody [EPR23668-64]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal IMPA2 antibody. Suitable for IP, WB and reacts with Human, Mouse, Rat, Transfected cell lysate - Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23668-64,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIMPA2 also known as Inositol Monophosphatase 2 is an enzyme with a mass of approximately 29 kDa. This protein is expressed predominantly in the brain particularly in regions such as the cerebellum and cerebral cortex. IMPA2 catalyzes the dephosphorylation of inositol monophosphate to free inositol an essential step in the phosphatidylinositol signaling pathway. This enzyme plays a significant role in maintaining inositol and inositol-derived compounds important for cellular functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIMPA2 influences cellular processes by managing inositol phosphate recycling and inositol availability. This enzyme does not typically function as part of a larger protein complex. Its activity helps control the levels of inositol in cells impacting signaling pathways that rely on phosphatidylinositol and its derivatives. Through this regulation IMPA2 supports functions like cell growth and survival indirectly affecting neurotransmission and hormone signaling.\u003cbr\u003e\nPathways\u003cbr\u003e\nIMPA2 assumes a central role in the phosphatidylinositol signaling pathway which influences a variety of cellular responses. It interacts closely with the phosphoinositide pathway sharing a relationship with proteins like G-protein coupled receptors and protein kinase C. The enzyme's activity ensures the continuous functioning of these pathways by supplying inositol an important molecule that these proteins need for activation and signaling transmission.\u003cbr\u003e\nResearchers have linked IMPA2 to bipolar disorder and schizophrenia. Reduced or altered activity of IMPA2 might contribute to imbalance in inositol signaling which is a hypothesis in the pathophysiology of these psychiatric conditions. The protein shows connections to other molecules involved in these disorders such as glycogen synthase kinase-3 (GSK3) which plays a role in mood regulation and neuroplasticity. Understanding the role of IMPA2 in these diseases could offer insights into potential therapeutic approaches.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850225471657,"sku":"ab256410","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab256410","provider":"Iright","version":"1.0","type":"link"}