{"product_id":"abcam-ab256513","title":"Abcam, ab256513, Anti-Orexin B antibody [EPR22803-18] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Orexin antibody. Carrier free. Suitable for ELISA, Dot, IHC-Fr, IHC-P and reacts with Synthetic peptide - Mouse, Mouse, Rat, Synthetic peptide samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22803-18,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:IHC-P, ELISA, Dot, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab256513 is the carrier-free version of\u003cbr\u003e\nab255293\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOrexin B also known as hypocretin 2 is a neuropeptide with a molecular mass of about 2 kDa. It is one of the two types of orexins the other being orexin A. Orexin B is produced in the lateral hypothalamus and is found mainly in the brain. The neuropeptide binds to the orexin receptor type 2 (HCRTR2) to initiate its actions. The lateral hypothalamus synthesizes orexin B and then it is distributed broadly across neurological circuits. Orexin B plays an important role in regulating wakefulness and food intake by interacting with its receptor.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOrexin B influences wakefulness energy metabolism and appetite regulation. It does not function alone but as part of the broader orexin neuropeptide system which includes orexin A and their respective receptors forming a regulatory network. The actions of orexin B impact the arousal system effectively enhancing alertness when appropriately activated. The neuropeptide's modulation of the sleep-wake cycle and feeding behaviors indicates its relevance in maintaining critical homeostatic circuits within the central nervous system.\u003cbr\u003e\nPathways\u003cbr\u003e\nOrexin B is significantly involved in the sleep-wake cycle and feeding regulatory pathways. Within these pathways orexin B interacts closely with neurotransmitters and receptors like norepinephrine and the HCRTR2 receptor. This interaction supports its role in maintaining wakefulness and energy balance. During activation orexin B influences the locus coeruleus an important site of noradrenergic neuron activity linking it to broader neurophysiological processes critical to arousal and stress response mechanisms.\u003cbr\u003e\nDisruptions in orexin B activity lead to conditions such as narcolepsy and obesity. Narcolepsy a sleep disorder characterized by debilitating daytime drowsiness connects to changes in orexin signaling particularly those affecting orexin receptors and their interaction with orexin A. Orexin B's relation to obesity stems from its influence on food intake and energy balance bridging metabolic disorders and neuropathological conditions. Research into these connections emphasizes the therapeutic potential of targeting this neuropeptide system to manage sleep disorders and metabolic diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860458131625,"sku":"ab256513","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab256513","provider":"Iright","version":"1.0","type":"link"}