{"product_id":"abcam-ab25888","title":"Abcam, ab25888, Anti-West Nile Virus preM antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal POLG antibody. Suitable for ELISA and reacts with West Nile virus samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:West Nile virus,\u003cbr\u003e\nApplications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nWest Nile Virus preM also known as WNV preM is a small envelope glycoprotein that plays an important role in the virus's assembly and maturation. The preM protein weighs approximately 26 kilodaltons forming part of the structural assembly of the virus particle. Primarily expressed in virus-infected host cells the preM protein is initially produced as a precursor that undergoes post-translational modifications. These processes prepare it to protect the viral envelope protein E which is critical during the maturation of the virus as it exits host cells and becomes infectious.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe preM protein ensures proper folding and transportation of the virus structural proteins assisting in the assembly and release of mature West Nile Virus particles. It forms a complex with E protein with preM stabilizing E and preventing premature fusion with host membranes during the virus's exit. The close interaction between preM and its complex partner E occurs primarily in the endoplasmic reticulum of the host cells and this interaction governs the virus's infectivity and immune evasion tactics.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe preM protein intricately ties into the viral entry and budding pathways of West Nile Virus replication cycle. Within the budding pathway preM interacts closely with the E protein to tightly control the release of mature viral particles from the host cell. This function of preM is also implicitly connected with cellular trafficking pathways which are important for the delivery and localization of viral components. Therefore the structural interactions guided by preM support the efficient replication and propagation of the virus within the host.\u003cbr\u003e\nThe preM protein of West Nile Virus is directly connected to viral encephalitis and febrile illness common outcomes of human infection. The proteomic interplay between preM and E during virus maturation influences viral pathogenicity significantly impacting disease severity. The efficient formation of infectious viral particles mediated by preM also increases the virulence of West Nile Virus linking it intricately with the severity of symptoms observed in infections. Understanding these connections helps in developing therapeutic approaches targeting these viral proteins to manage or prevent disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848616136873,"sku":"ab25888","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab25888","provider":"Iright","version":"1.0","type":"link"}