{"product_id":"abcam-ab263021","title":"Abcam, ab263021, Anti-MLLT6 antibody [EPR20977-52] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Recombinant Monoclonal MLLT6 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR20977-52,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab263021 is the carrier-free version of\u003cbr\u003e\nab208017\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe MLLT6 protein also known as AF17 functions mechanically as a transcriptional coactivator. It plays a role in regulating gene expression by interacting with other proteins involved in transcriptional control. The protein has a mass of approximately 122 kDa. Researchers identify its expression in various tissues with a significant presence in hematopoietic tissues. MLLT6 interacts closely with other protein partners to modulate the transcriptional machinery.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMLLT6 acts as a part of larger protein complexes involved in transcription regulation. It influences the activation and repression of specific gene sets necessary for cell differentiation and development. By integrating into these complexes MLLT6 assists in maintaining the proper function of gene expression programs that control cellular identity and activity. Its contribution is important in processes such as hematopoiesis impacting the development and specialization of blood cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nMLLT6 plays a role in key regulatory networks like the mitochondrial apoptosis and Notch signaling pathways. Through interactions within these pathways MLLT6 associates with proteins like MLLT3 and NOTCH1. These relationships help mediate cell survival proliferation and differentiation signals. This pathway integration allows MLLT6 to influence essential cellular processes aligning transcriptional responses with extracellular signals.\u003cbr\u003e\nMLLT6 shows a strong connection to certain types of leukemia notably acute myeloid leukemia (AML). Dysregulation of MLLT6 can contribute to leukemogenesis by disrupting normal transcriptional programs and signaling pathways. Additionally studies link MLLT6 to neuroblastoma where its aberrant expression intersects with the MLL protein family impacting tumor development. These disease associations highlight MLLT6's potential value as a therapeutic target and a biomarker for specific hematological and neurological malignancies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851735027881,"sku":"ab263021","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab263021","provider":"Iright","version":"1.0","type":"link"}