{"product_id":"abcam-ab263122","title":"Abcam, ab263122, Human C19orf24 knockout HEK-293T cell lysate","description":"\u003cp\u003eSize: 1Kit\u003cbr\u003e\nFAM174C KO cell lysate available now. KO validated by. Free of charge wild type control included. Knockout achieved by using CRISPR\/Cas9, Insertion of the selection cassette in exon1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Insertion of the selection cassette in exon1.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nKnockout cell lysate achieved by CRISPR\/Cas9.\u003cbr\u003e\nREACH authorisation\u003cbr\u003e\nAbcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.\u003cbr\u003e\nIt is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.\u003cbr\u003e\nLysate preparation:\u003cbr\u003e\nOur lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10).\u003cbr\u003e\nThis means that the protein of interest is denatured.\u003cbr\u003e\nIf you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.\u003cbr\u003e\nUser storage instructions:\u003cbr\u003e\nLyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-FAM174C, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nC19orf24 also known as C19orf71 or Chromosome 19 Open Reading Frame 24 is a protein that participates in key cellular mechanisms. This protein weighs approximately 13 kDa. It is primarily expressed in several tissues including the liver lung and spleen. Its exact mechanical role remains under investigation but current research indicates that it plays important roles in cellular signaling and regulatory functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein encoded by C19orf24 has interactions that suggest roles in cellular and molecular processes. It is not part of a known larger protein complex. Evidence suggests involvement in cytokine signaling and response making it an interesting target for studies focused on immune response and inflammation. The identification of specific binding partners remains an ongoing area of research as understanding these interactions could clarify its biological roles further.\u003cbr\u003e\nPathways\u003cbr\u003e\nMultiple cytokine mediated signaling pathways involve C19orf24 especially in relation to immune system regulation. It contributes to key pathways like the IL-6 signaling which is important for inflammatory response and possibly interacts with related proteins such as STAT3 a well-known signaling molecule in immune reactions. Continued mapping of these pathways will help elucidate the broader impact of C19orf24 on cellular functions.\u003cbr\u003e\nCurrent studies connect C19orf24 to autoimmune conditions and inflammatory disorders such as rheumatoid arthritis. The protein's potential interaction with cytokine pathways and proteins like TNF-alpha which play significant roles in inflammatory responses hints at its contribution to these diseases. Further examination is required to fully understand C19orf24's impact on disease progression and its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845218291881,"sku":"ab263122","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab263122","provider":"Iright","version":"1.0","type":"link"}