{"product_id":"abcam-ab264501","title":"Abcam, ab264501, Ramucirumab ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nRamucirumab ELISA Kit is a Quantitative ELISA for the measurement of Ramucirumab in Human in Biofluids samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Plasma, Serum,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Quantitative,\u003cbr\u003e\nSensitivity:= 20 ng\/mL,\u003cbr\u003e\nRange:20 - 600 ng\/mL,\u003cbr\u003e\nAssay Platform:Microplate\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nNote: Ramucirumab ELISA kit ab264501 is intended for Research Use Only, not for use in diagnostic procedures.\u003cbr\u003e\nThis kit is a sandwich based ELISA kit. The color developed is proportional to the amount of Ramucirumab in the sample or standard. Results of samples can be determined directly using the standard curve.\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called E4698 BioSim™ Ramucirumab (Human) ELISA Kit. E4698-100 is the same size as the 1 x 96 tests size of ab264501.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRamucirumab is a monoclonal antibody that targets vascular endothelial growth factor receptor 2 (VEGFR-2). It specifically binds to the extracellular domain of VEGFR-2 inhibiting its ability to interact with its natural ligands. VEGFR-2 has a mass of around 150 kDa and is primarily expressed on endothelial cells which line the blood vessels. Ramucirumab acts by blocking angiogenic signals which are critical for new blood vessel formation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nVEGFR-2 is an important component in the angiogenesis process which is the formation of new blood vessels from pre-existing ones. It is part of the plasma membrane-spanning receptor tyrosine kinase family. Upon ligand binding VEGFR-2 undergoes dimerization and autophosphorylation activating downstream signaling pathways. These pathways promote endothelial cell proliferation migration and survival. VEGFR-2's role in vessel permeability and inflammation also contributes to its biological significance.\u003cbr\u003e\nPathways\u003cbr\u003e\nVEGFR-2 is integral within the VEGF signaling pathway and endothelial cell signaling pathways. It closely interacts with vascular endothelial growth factor A (VEGF-A) as its main ligand. This interaction triggers a cascade involving phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinases (MAPK) which are important for vascular development and maintenance. VEGFR-2's activity is balanced by its relation to other receptors like VEGFR-1 ensuring proper vessel formation and function.\u003cbr\u003e\nRamucirumab has shown effectiveness for conditions such as gastric cancer and colorectal cancer. These diseases often exhibit abnormal angiogenesis which is important for tumor growth and metastasis. VEGFR-2 is upregulated in these cancers making it a target for therapeutic intervention. Ramucirumab's binding to VEGFR-2 prevents VEGF-mediated tumor vascularization and progression. Its relationship with other proteins such as fibroblast growth factor receptors (FGFRs) in cancer highlights the complexity of angiogenic signaling in malignancies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843654930601,"sku":"ab264501","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab264501","provider":"Iright","version":"1.0","type":"link"}